European Journal of Medicinal Chemistry p. 285 - 289 (1992)
Update date:2022-08-17
Topics:
Audin, P
Sarciron, ME
Paris, J
Petavy, AF
In our search for effective chemotherapy of alveolar hydatid disease we are investigating key enzymes of Echinococcus multilocularis metacestodes.Isatin (2,3-indolinedione) is well known as an inhibitor of alkaline phosphatase activity, and has been previously investigated.Acetylcarboxanilide, an "open drug" of isatin and 2 methacrylanilides were evaluated for their ability to inhibit alkaline phosphatase activity of Echinococcus multilocularis metacestodes in vivo.These "open drugs" are more efficient than isatin, and para-chloromethacrylanilide exhibits a strongselectivity for the parasite enzyme and is also effective in vitro.The results obtained with para-chloromethacrylanilide are promising.Echinococcus multilocularis / alkaline phosphatase / synthetic inhibitors /anilides
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