Macromolecules
Article
In conclusion, we fabricated biodegradable SP-PCL nano-
particles capable of undergoing reversible fluorescence switch-
ing with alternating UV (<420 nm) and visible (>420 nm)
light. The outstanding advantages of photoswitchable SP-PCL
nanoparticles, e.g., fast response, good stability and robustness,
and great biocompatibility and biodegradability, endow them to
act as excellent fluorescent probes in super-resolution imaging.
The localization-based super-resolution fluorescence imaging
results demonstrate that vicinal SP-PCL nanoparticles are
discernible with sub-50 nm resolution, which is much higher
than that obtained with conventional fluorescent imaging.
In addition to their promising application in bioimaging, we
expect that such high signal-to-noise, environmentally friendly,
and fluorescence-switchable nanomaterials will exhibit potential
utility in many fields like smart inks and photosensitive displays.
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Author Contributions
§
G.-F.Z. and Z.H. contributed equally to this work.
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nle, A.;
Notes
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The authors declare no competing financial interest.
J. F.; Raymo, F. M. J. Am. Chem. Soc. 2011, 133, 871−879. (b) Gu, H.;
ACKNOWLEDGMENTS
Bi, L.; Fu, Y.; Wang, N.; Liu, S.; Tang, Z. Chem. Sci. 2013, 4, 4371−
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377. (c) Liu, Z.; Tang, Z. Nano Today 2010, 5, 267−281. (d) Qin, B.;
This work was supported by the National Science Foundation of
China (NSFC 21174045, 30970691, 30925013, and 51033005)
and National Basic Research Program of China (2013CB922104,
Chen, H.; Liang, H.; Fu, L.; Liu, X.; Qiu, X.; Liu, S.; Song, R.; Tang, Z.
J. Am. Chem. Soc. 2010, 132, 2886−2888.
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26) Ercole, F.; Davis, T. P.; Evans, R. A. Polym. Chem. 2010, 1, 37−
2
011CB910401). M.P.A. is the Foreign Young Investigator
5
Awardee of NSFC (21150110141 and 21250110572). We also
gratefully thank the support from the Analysis Center in
Huazhong University of Science and Technology.
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dx.doi.org/10.1021/ma5001157 | Macromolecules 2014, 47, 1543−1552