Bioorganic and Medicinal Chemistry Letters p. 2231 - 2236 (1996)
Update date:2022-08-16
Topics:
Hernandez-Luis, Francisco
Castillo, Rafael
Yepez-Mulia, Lilian
Cedillo-Rivera, Roberto
Martinez-Vazquez, Gabriel
Morales-Hurtado, Raul
Jung, Helgi
Sanchez, Monica
Hernandez-Campos, Alicia
Viveros, Noemi
Munoz, Onofre
N-methoxycarbonyl-N'-(2-nitro-4-propylthiophenyl)thiourea and N-methoxycarbonyl-N'-(2-nitro-5-propylthiophenyl)thiourea, prodrugs of albendazole, have been synthesized. The biotransformation in rats, after oral administration of these prodrugs to albendazole and albendazole sulphoxide, is described.
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