European Journal of Medicinal Chemistry p. 361 - 369 (2015)
Update date:2022-08-16
Topics:
Mostofi, Manizheh
Mohammadi Ziarani, Ghodsi
Mahdavi, Mohammad
Moradi, Alireza
Nadri, Hamid
Emami, Saeed
Alinezhad, Heshmatollah
Foroumadi, Alireza
Shafiee, Abbas
A series of benzofuran-based chalconoids 6a-v were designed and synthesized as new potential AChE inhibitors. The in vitro assay of synthesized compounds 6a-v showed that most compounds had significant anti-AChE activity at micromolar or sub-micromolar levels. Among the tested compounds, 3-pyridinium derivative 6m bearing N-(2-bromobenzyl) moiety and 7-methoxy substituent on the benzofuran ring exhibited superior activity. This compound with IC50 value of 0.027 μM was as potent as standard drug donepezil.
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Doi:10.1021/jm030225v
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