Recombinant Fabs Specific for Coplanar PCBs
J. Agric. Food Chem., Vol. 48, No. 6, 2000 2623
Ekins, R. P.; Chu, F. W.; Biggart, E. M. Multispot, multiana-
lyte immunoassay. Ann. Biol. Clin. 1990b, 48, 655-666.
Erickson, M. D. Analytical Chemistry of PCBs; CRC/Lewis
Publishing: Boca Raton, FL, 1997.
Karu, A. E.; Lesnik, B.; Haas, R. A. Polychlorinated biphe-
nyls: detection by immunoassay. In Encyclopedia of Envi-
ronmental Analysis and Remediation; Myers, R. A., Ed.;
Wiley: New York, 1998; pp 3798-3814.
Font, G. M., J .; Molto, J . C.; Pico, Y. Current developments in
the analysis of water pollution by polychlorinated biphenyls.
J . Chromatogr. A 1996, 733, 449-471.
Golinelli-Pimpaneau, B.; Gigant, B.; Bizebard, T.; Navaza, J .;
Saludjian, P.; Zemel, R.; Tawfik, D. S.; Eshhar, Z.; Green,
B. S.; Knossow, M. Crystal structure of a catalytic antibody
Fab with esterase-like activity. Structure (London) 1994, 2,
Lamb, B. T.; Sisodia, S. S.; Lawler, A. M.; Slunt, H. H.; Kitt,
C. A.; Kearns, W. G.; Pearson, P. L.; Price, D. L.; Gearhart,
J . D. Introduction and expression of the 400 kilobase
precursor amyloid protein gene in transgenic mice. Nat.
Genet. 1993, 5, 22-30.
Lane, P.; Burdet, C.; Hubele, S.; Scheidegger, D.; Muller, U.;
McConnell, F.; Kosco-Vilbois, M. B cell function in mice
transgenic for mCTLA4-H-gamma-1: Lack of germinal
centers correlated with poor affinity maturation and class
switching despite normal priming of CD4+ T cells. J . Exp.
Med. 1994, 179, 819-830.
1
75-183.
Hanahan, D. Techniques for transformation of E. coli. In DNA
Cloning: A Practical Approach; Glover, D. M., Ed.; IRL
Press: Oxford, U.K., 1985; pp 109-121.
Hansen, L. G. Stepping backward to improve assessment of
PCB congener toxicities. Environ. Health Perspect. 1998,
Lee, N.; Holtzapple, C. K.; Stanker, L. H. Cloning, expression,
and characterization of recombinant Fab antibodies against
dioxin. J . Agric. Food Chem. 1998, 46, 3381-3388.
Lesk, A. M.; Tramontano, A. Antibody structure and structural
predictions useful in guiding antibody engineering. In
Antibody Engineering: A Practical Guide; Borrebaeck, C.
A. K., Ed.; Freeman: New York, 1992; pp 1-38.
1
06, 171-89.
Hard, T.; Barnes, H. J .; Larsson, C.; Gustafsson, J . A.; Lund,
J . Solution structure of a mammalian PCB-binding protein
in complex with a PCB [see comments]. Nat. Struct. Biol.
1
995, 2, 983-989.
Harlow, E.; Lane, D. Antibodies: A Laboratory Manual; Cold
Spring Harbor Laboratory: Cold Spring Harbor, NY, 1988.
Healey, B. G.; Li, L.; Walt, D. R. Multianalyte biosensors on
optical imaging bundles. Biosensors Bioelectronics 1997, 12,
Lesley, S. A.; Patten, P. A.; PG, S. A genetic approach to the
generation of antibodies with enhanced catalytic activities.
Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 1160-1165.
Maniatis, T.; Fritsch, E. F.; Sambrook, J . Molecular Cloning,
A Laboratory Manual; Cold Spring Harbor Laboratory: Cold
Spring Harbor, NY, 1989.
Marks, J . D.; Hoogenboom, H. R.; Bonnert, T. P.; McCafferty,
J .; Griffiths, A. D.; Winter, G. By-passing immunization:
Human antibodies from V-gene libraries displayed on phage.
J . Mol. Biol. 1991, 222, 581-597.
5
21-529.
Hirano, H. Sequence analysis of the NH-2-terminally blocked
proteins immobilized on PVDF membranes from polyacry-
lamide gels. In Springer Lab Manual: Protein Structure
Analysis: Preparation, Characterization, and Microsequenc-
ing; Kamp, R. M. T. C.-P., Wittmann-Liebold, B., Eds.;
Springer-Verlag: Berlin, Germany, 1997; pp 167-179.
Hsiao, H.-Y.; Royer, G. P. Immobilization of glycoenzymes
through carbohydrate side chains. Arch. Biochem. Biophys.
Martin, A. C. R. Accessing the Kabat antibody sequence
database by computer. Proteins: Struct., Funct. Genet. 1996,
25, 130-133.
1
979, 198, 379-385.
McFarland, V. A.; Clarke, J . U. Environmental occurrence,
abundance, and potential toxicity of polychlorinated biphe-
nyl congeners: considerations for a congener-specific analy-
sis. Environ. Health Perspect. 1989, 81, 225-239.
Mes, J .; Conacher, H. B. S.; Malcolm, S. An international study
on feasibility of estimating polychlorinated biphenyls by
using specific polychlorinated biphenyl congeners. Int. J .
Environ. Anal. Chem. 1993, 50, 285-297.
Mizutani, R.; Miura, K.; Nakayama, T.; Shimada, I.; Arata,
Y.; Satow, Y. Three-dimensional structures of the Fab
fragment of murine N1G9 antibody from the primary
immune response and of its complex with (4-hydroxy-3-
nitrophenyl)acetate. J . Mol. Biol. 1995, 254, 208-222.
Nord, M.; Gustafsson, J . A.; Lund, J . Calcium-dependent
binding of uteroglobin (PCB-BP/CCSP) to negatively charged
phospholipid liposomes. FEBS Lett. 1995, 374, 403-406.
Padlan, E. A. Anatomy of the antibody molecule. Mol. Immu-
nol. 1994, 31, 169-217.
J anda, K. D.; Lo, L.-C.; Lo, C.-H.; Sim, M.-M.; Wang, R.; Wong,
C.-H.; Lerner, R. A. Chemical selection for catalysis in
combinatorial antibody libraries. Science 1997, 275, 945-
9
48.
J ohnson, G.; Wu, T. T.; Kabat, E. A. Seqhunt: A program to
screen aligned nucleotide and amino acid sequences. In
Methods in Molecular Biology, Vol. 51. Antibody Engineering
Protocols; Paul, S., Ed.; Humana Press: Totowa, NJ , 1995;
pp 1-15.
J ones, G.; Wortberg, M.; Kreissig, S. B.; Bunch, D. S.; Gee, S.
J .; Hammock, B. D.; Rocke, D. M. Extension of the four-
parameter logistic model for ELISA to multianalyte analy-
sis. J . Immunol. Methods 1994, 177, 1-7.
J ones, K. C. Determination of polychlorinated biphenyls in
human foodstuffs and tissues: suggestions for a selective
congener analytical approach. Sci. Total Environ. 1988, 68,
1
41-159.
Kabat, E. A.; Wu, T. T.; Perry, H. M.; Gottesman, K. S.; Foeller,
C. Sequences of Proteins of Immunological Interest; Public
Health Service, NIH: Washington, DC, 1991.
Kafafi, S. A.; Afeefy, H. Y.; Ali, A. H.; Said, H. K.; Ad-Elazem,
I. S.; Kafafi, A. G. Affinities for the aryl hydrocarbon
receptor, potencies as aryl hydrocarbon hydroxylase induc-
ers and relative toxicities of polychlorinated biphenyls: A
congener specific approach. Carcinogenesis (Oxford) 1993,
Radbruch, A.; Zaiss, S.; Kappen, C.; Bruggemann, M.; Bey-
reuther, K.; Rajewsky, K. Drastic change in idiotypic but
not antigen-binding specificity of an antibody by a single
amino acid substitution. Nature 1985, 315, 506-508.
Recinos, A., 3rd; Silvey, K. J .; Ow, D. J .; J ensen, R. H.;
Stanker, L. H. Sequences of cDNAs encoding immunoglo-
bulin heavy- and light-chain variable regions from two anti-
dioxin monoclonal antibodies. Gene 1994, 149, 385-386
(published erratum appears in Gene 1995, 158, 311).
Research Triangle Institute. Toxicological Profile for Polychlo-
rinated Biphenyls; Report to the U.S. Department of Health
and Human Services, Public Health Services, Agency for
Toxic Substances and Disease Registry; 1997.
1
4, 2063-2071.
Kang, A. S.; Burton, D. R.; Lerner, R. A. Combinatorial
Immunoglobulin Libraries in Phage Lambda. In Methods:
A Companion to Methods in Enzymology; Academic Press:
San Diego, CA, 1991; Vol. 2, pp 111-118.
Karu, A. E.; Belk, E. D. Induction of E. coli recA protein via
recBC and alternate pathways: quantitation by enzyme-
linked immunosorbent assay (ELISA). Mol. Gen. Genet.
Risby, T. H.; Hsu, T.-B.; Sehnert, S. S.; Bhan, P. Physicochem-
ical parameters of individual hexachlorobiphenyl congeners.
Environ. Sci. Technol. 1990, 24, 1680-1687.
Rosowsky, A.; Chen, K. K. N.; Lin, M.; Nadel, M. E.; St.
Amand, R.; Yeager, S. A. Synthesis of two new heterocyclic
ring systems: benzo[3,4]cyclohepta[1,2-d]pyrimidines and
benzo[3,4]cyclohepta[2,1-d]pyrimidines (1,2). J . Heterocycl.
Chem. 1971, 8, 789-795.
1
982, 185, 275-282.
Karu, A. E.; Goodrow, M. H.; Schmidt, D. J .; Hammock, B.
D.; Bigelow, M. W. Synthesis of haptens and derivation of
monoclonal antibodies for immunoassay of the phenylurea
herbicide diuron. J . Agric. Food Chem. 1994, 42, 301-309.