Journal of Medicinal Chemistry p. 1205 - 1214 (2015)
Update date:2022-08-10
Topics:
Devine, Shane M.
Mulcair, Mark D.
Debono, Cael O.
Leung, Eleanor W. W.
Nissink, J. Willem M.
Lim, San Sui
Chandrashekaran, Indu R.
Vazirani, Mansha
Mohanty, Biswaranjan
Simpson, Jamie S.
Baell, Jonathan B.
Scammells, Peter J.
Norton, Raymond S.
Scanlon, Martin J.
We have identified a class of molecules, known as 2-aminothiazoles (2-ATs), as frequent-hitting fragments in biophysical binding assays. This was exemplified by 4-phenylthiazol-2-amine being identified as a hit in 14/14 screens against a diverse range of
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