YUAN ET AL.
9
10. Higuchi A, Tamai M, Ko YA, et al. Polymeric membranes for chiral
separation of pharmaceuticals and chemicals. Polymer Rev.
2010;50:113‐143.
4 | CONCLUSION
Chiral separations of D,L‐mandelic acid or D,L‐p‐hydroxy
phenylglycine may be realized via dialysis through
solid membranes of cellulose, sodium alginate, or
hydroxypropyl‐β‐cyclodextrin. The enantiomeric excess
values can be affected by the membrane material concentra-
tions, membrane preparation conditions, and feed concentra-
tions. The chiral separation by the membranes is possibly a
result of adsorption of one kind of enantiomer followed by
association of the opposite enantiomer and then diffusion of
the opposite configuration enantiomer. The chiral adsorption
depends on the enantioselective properties of the membrane.
The association of the opposite configuration enantiomer is
related to the characteristics of the racemate. The diffusion
of the opposite configuration enantiomer is a result of the
concentration difference. This study will be very useful for
the development of optical resolution membranes.
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cyclodexytrin‐modified chiral membrane. Trans Beijing Inst
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ACKNOWLEDGEMENTS
17. Bushell AF, Budd PM, Attfield MP, et al. Nanoporous organic
polymer/cage composite membranes. Angew Chem Int Ed.
2013;52:1253‐1256.
This work was supported by the National Nature Science
Foundation of China (21365025, 21265026 and 21165022).
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polymers of intrinsic microporosity: Selective membrane perme-
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