Journal of labelled compounds and radiopharmaceuticals p. 1061 - 1070 (1996)
Update date:2022-08-11
Topics:
Haeckel, Roland
Weber, Klaus
Germann, Christine
Haberkorn, Uwe
Zeisler, Stefan
Eisenbarth, Joseph
Wiessler, Manfred
Oberdorfer, Franz
Several nucleoside analogues like 1-(β-D-glucopyranosyl)-5-fluorouracil 10, 1-(β-D-galactopyranosyl)-5-fluorouracil 11 and 1-(2-deoxy-β-D-glucopyranosyl)- 5-fluorouracil 12 have been synthesized. From the corresponding 1-(2',3',4',6'-tetra-O-acetyl-β-D-glycopyranosyl)-uracil 4, 5 and 6, the 18F labelled compounds 16, 17 and 18 have been prepared via the intermediates 13, 14 and 15 in acetic acid using [18F]F2 and acidic deacetylating procedures. The 18F labelled derivatives could be obtained, following preparative chromatography, in high purity and in yields of about 3.108 Bq - 5.7·108 Bq (18% - 34% related to the trapped radioactivity, not corrected for decay) for their in-vine evaluation and for in-vivo studies with PET.
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