Inorganica Chimica Acta p. 166 - 175 (2018)
Update date:2022-08-17
Topics:
Nazir, Shahbaz
Anwar, Jamil
Munawar, Munawar Ali
Qazi, Javed Iqbal
Best, Stephen Peter
Cheah, Michael
Muhammad Yaseen
Anti-microbial effect is produced when the ligand (L) S-ethyl-L-cysteine sulfoxide (Ethiin) makes coordination complex with metal ‘M’ (M = Cu, Co, Ni), while, ethiin did not show any antimicrobial effect. The synthesized complexes have 1:2 metal to ligand ratio (ML2). The spectro-chemical analysis revealed that the ligand coordinates with the metals through oxygens of the carboxylate and sulfoxide groups resulting in octahedral geometry around the central metal atom. Techniques like 1H NMR, thermal analysis, mass spectrometry, UV-Vis spectroscopy, XAFS, FTIR, EPR and magnetic moments were used to elucidate the structure of the ligand and the metal complexes. The expected reasons for the creation of anti-microbial effect are, either the disturbance of the ionic environment within the microbial cytoplasm when the complex enters into it or interaction of the complex with the DNA.
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