Synthetic Communications p. 1829 - 1835 (2006)
Update date:2022-08-29
Topics:
Dai, Hong-Guang
Li, Ji-Tai
Li, Tong-Shuang
An efficient and practical procedure for the Mannich reaction of secondary amine, formaldehyde, and indole or N-methylindole employing zinc chloride is presented. A series of gramine derivatives were obtained in 58-98% yields at room temperature in EtOH by using this method. Copyright Taylor & Francis Group, LLC.
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