Wang et al.
9
4
4
0. Hanahan D, Weinberg RA. The hallmarks of
cancer. Cell 2000;100:57–70.
differentiation thus promoting hepatocellular
carcinoma immune evasion. Nat Commun 2017;
8:15129.
ERK1/2/HIF-1alpha/VEGFA signalling in
hepatocellular carcinoma. J Exp Clin Cancer Res
2018;37:113.
1. Zhang D, Zhang G, Hu X, et al. Oncogenic RAS
regulates long noncoding RNA Orilnc1 in
human cancer. Cancer Res 2017;77:3745–57.
2. Chen D, Zhang Z, Mao C, et al. ANRIL inhibits
p15(INK4b) through the TGFbeta1 signaling
pathway in human esophageal squamous cell
carcinoma. Cell Immunol 2014;289:91–6.
58. Cui H, Xie N, Tan Z, et al. The human long
noncoding RNA lnc-IL7R regulates the inflam-
matory response. Eur J Immunol 2014;44:
2085–95.
59. Chen CL, Tseng YW, Wu JC, et al. Suppression
of hepatocellular carcinoma by baculovirus-
mediated expression of long non-coding RNA
PTENP1 and MicroRNA regulation. Biomate-
rials 2015;44:71–81.
60. Chen ZH, Wang WT, Huang W, et al. The
lncRNA HOTAIRM1 regulates the degradation
of PML-RARA oncoprotein and myeloid cell dif-
ferentiation by enhancing the autophagy path-
way. Cell Death Differ 2017;24:212–24.
61. Qin R, Chen Z, Ding Y, et al. Long non-coding
RNA MEG3 inhibits the proliferation of cervical
carcinoma cells through the induction of cell
cycle arrest and apoptosis. Neoplasma 2013;60:
486–92.
62. Guo Q, Qian Z, Yan D, et al. LncRNA-MEG3
inhibits cell proliferation of endometrial carci-
noma by repressing notch signaling. Biomed
Pharmacother 2016;82:589–94.
63. Peng W, Si S, Zhang Q, et al. Long non-coding
RNA MEG3 functions as a competing endoge-
nous RNA to regulate gastric cancer progression.
J Exp Clin Cancer Res 2015;34:79.
64. Luo G, Wang M, Wu X, et al. Long non-coding
RNA MEG3 inhibits cell proliferation and
induces apoptosis in prostate cancer. Cell Physiol
Biochem 2015;37:2209–20.
65. Lu KH, Li W, Liu XH, et al. Long non-coding
RNA MEG3 inhibits NSCLC cells proliferation
and induces apoptosis by affecting p53 expres-
sion. BMC Cancer 2013;13:461.
66. Wang M, Huang T, Luo G, et al. Long non-
coding RNA MEG3 induces renal cell carcinoma
cells apoptosis by activating the mitochondrial
pathway. J Huazhong Univ Sci Technolog Med
Sci 2015;35:541–5.
67. Cusanelli E, Chartrand P. Telomeric repeat-
containing RNA TERRA: a noncoding RNA
connecting telomere biology to genome integrity.
Front Genet 2015;6:143.
68. He X, Tan X, Wang X, et al. C-Myc-activated
long noncoding RNA CCAT1 promotes colon
cancer cell proliferation and invasion. Tumour
Biol 2014;35:12181–8.
69. Zhang Y, Ma M, Liu W, et al. Enhanced expres-
sion of long noncoding RNA CARLo-5 is associ-
ated with the development of gastric cancer. Int
J Clin Exp Pathol 2014;7:8471–9.
70. Yang F, Xue X, Bi J, et al. Long noncoding RNA
CCAT1, which could be activated by c-Myc, pro-
motes the progression of gastric carcinoma.
J Cancer Res Clin Oncol 2013;139:437–45.
71. Zhu H, Zhou X, Chang H, et al. CCAT1 pro-
motes hepatocellular carcinoma cell proliferation
and invasion. Int J Clin Exp Pathol 2015;8:
5427–34.
72. Luo J, Tang L, Zhang J, et al. Long non-coding
RNA CARLo-5 is a negative prognostic factor
and exhibits tumor pro-oncogenic activity in
non-small cell lung cancer. Tumour Biol 2014;35:
11541–9.
74. Yuan SX, Yang F, Yang Y, et al. Long noncoding
RNA associated with microvascular invasion in
hepatocellular carcinoma promotes angiogenesis
and serves as a predictor for hepatocellular carci-
noma patients’ poor recurrence-free survival
after hepatectomy. Hepatology 2012;56:2231–41.
75. Zhang Y, Li Z, Zhang Y, et al. Molecular mecha-
nism of HEIH and HULC in the proliferation
and invasion of hepatoma cells. Int J Clin Exp
Med 2015;8:12956–62.
76. Li SP, Xu HX, Yu Y, et al. LncRNA HULC
enhances epithelial-mesenchymal transition to
promote tumorigenesis and metastasis of hepato-
cellular carcinoma via the miR-200a-3p/ZEB1
signaling pathway. Oncotarget 2016;7:42431–46.
77. Zhao Y, Guo Q, Chen J, et al. Role of long
non-coding RNA HULC in cell proliferation,
apoptosis and tumor metastasis of gastric cancer:
a clinical and in vitro investigation. Oncol Rep
2014;31:358–64.
78. Zhu Y, Zhang X, Qi L, et al. HULC long non-
coding RNA silencing suppresses angiogenesis
by regulating ESM-1 via the PI3K/Akt/mTOR
signaling pathway in human gliomas. Oncotarget
2016;7:14429–40.
79. Lu Z, Xiao Z, Liu F, et al. Long non-coding RNA
HULC promotes tumor angiogenesis in liver
cancer by up-regulating sphingosine kinase
1 (SPHK1). Oncotarget 2016;7:241–54.
80. Xiong J, Liu Y, Jiang L, et al. High expression of
long non-coding RNA lncRNA-ATB is corre-
lated with metastases and promotes cell migra-
tion and invasion in renal cell carcinoma. Jpn J
Clin Oncol 2016;46:378–84.
81. Xue M, Pang H, Li X, et al. Long non-coding
RNA urothelial cancer-associated 1 promotes
bladder cancer cell migration and invasion by
way of the hsa-miR-145-ZEB1/2-FSCN1 path-
way. Cancer Sci 2016;107:18–27.
82. Huang J, Zhou N, Watabe K, et al. Long non-
coding RNA UCA1 promotes breast tumor
growth by suppression of p27 (Kip1). Cell Death
Dis 2014;5:e1008.
83. Xiao C, Wu CH, Hu HZ. LncRNA UCA1 pro-
motes epithelial-mesenchymal transition (EMT)
of breast cancer cells via enhancing Wnt/beta-
catenin signaling pathway. Eur Rev Med
Pharmacol Sci 2016;20:2819–24.
84. Li Y, Wang T, Li Y, et al. Identification of long-
non coding RNA UCA1 as an oncogene in renal
cell carcinoma. Mol Med Rep 2016;13:3326–34.
85. Li W, Xie P, Ruan WH. Overexpression of
lncRNA UCA1 promotes osteosarcoma progres-
sion and correlates with poor prognosis. J Bone
Oncol 2016;5:80–5.
86. Nie W, Ge HJ, Yang XQ, et al. LncRNA-UCA1
exerts oncogenic functions in non-small cell lung
cancer by targeting miR-193a-3p. Cancer Lett
2016;371:99–106.
87. Wei Y, Sun Q, Zhao L, et al. LncRNA
UCA1-miR-507-FOXM1 axis is involved in cell
proliferation, invasion and G0/G1 cell cycle
arrest in melanoma. Med Oncol 2016;33:88.
88. Ke J, Yao YL, Zheng J, et al. Knockdown of long
non-coding RNA HOTAIR inhibits malignant
biological behaviors of human glioma cells via
modulation of miR-326. Oncotarget 2015;6:
21934–49.
4
4
3. Zhang EB, Kong R, Yin DD, et al. Long noncod-
ing RNA ANRIL indicates a poor prognosis of
gastric cancer and promotes tumor growth by
epigenetically silencing of miR-99a/miR-449a.
Oncotarget 2014;5:2276–92.
4
4. Lu Y, Zhou X, Xu L, et al. Long noncoding RNA
ANRIL could be transactivated by c-Myc and
promote tumor progression of non-small-cell
lung cancer. Onco Targets Ther 2016;9:3077–84.
5. Zhu H, Li X, Song Y, et al. Long non-coding
RNA ANRIL is up-regulated in bladder cancer
and regulates bladder cancer cell proliferation
and apoptosis through the intrinsic pathway.
Biochem Biophys Res Commun 2015;467:223–8.
6. Qiu JJ, Lin YY, Ding JX, et al. Long non-coding
RNA ANRIL predicts poor prognosis and pro-
motes invasion/metastasis in serous ovarian
cancer. Int J Oncol 2015;46:2497–505.
4
4
4
7. Zhao JJ, Hao S, Wang LL, et al. Long non-coding
RNA ANRIL promotes the invasion and metas-
tasis of thyroid cancer cells through TGF-
beta/Smad signaling pathway. Oncotarget 2016;7:
57903–18.
4
4
5
8. Liu Z, Wang W, Jiang J, et al. Downregulation of
GAS5 promotes bladder cancer cell proliferation,
partly by regulating CDK6. PLoS One 2013;8:
e73991.
9. Sun M, Jin FY, Xia R, et al. Decreased expression
of long noncoding RNA GAS5 indicates a poor
prognosis and promotes cell proliferation in gas-
tric cancer. BMC Cancer 2014;14:319.
0. Chang L, Li C, Lan T, et al. Decreased expression
of long non-coding RNA GAS5 indicates a poor
prognosis and promotes cell proliferation and
invasion in hepatocellular carcinoma by regulat-
ing vimentin. Mol Med Rep 2016;13:1541–50.
1. Guo X, Deng K, Wang H, et al. GAS5 inhibits
gastric cancer cell proliferation partly by modu-
lating CDK6. Oncol Res Treat 2015;38:362–6.
2. Guo C, Song WQ, Sun P, et al. LncRNA-GAS5
induces PTEN expression through inhibiting
miR-103 in endometrial cancer cells. J Biomed
Sci 2015;22:100.
5
5
5
3. Lu X, Fang Y, Wang Z, et al. Downregulation of
gas5 increases pancreatic cancer cell proliferation by
regulating CDK6. Cell Tissue Res 2013;354:891–6.
4. Qiao HP, Gao WS, Huo JX, et al. Long non-
coding RNA GAS5 functions as a tumor sup-
pressor in renal cell carcinoma. Asian Pac J Can-
cer Prev 2013;14:1077–82.
5
5
5
5
5. Chen L, Yang H, Xiao Y, et al. Lentiviral-
mediated overexpression of long non-coding
RNA GAS5 reduces invasion by mediating
MMP2 expression and activity in human mela-
noma cells. Int J Oncol 2016;48:1509–18.
6. Diaz-Lagares A, Crujeiras AB, Lopez-Serra P,
et al. Epigenetic inactivation of the p53-induced
long noncoding RNA TP53 target 1 in human
cancer. Proc Natl Acad Sci U S A 2016;113:
E7535–44.
73. Lin J, Cao S, Wang Y, et al. Long non-coding
RNA UBE2CP3 enhances HCC cell secretion of
VEGFA and promotes angiogenesis by activating
7. Jiang R, Tang J, Chen Y, et al. The long noncod-
ing RNA lnc-EGFR stimulates T-regulatory cells
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