Tetrahedron Asymmetry p. 187 - 189 (1997)
Update date:2022-08-11
Topics:
Wirz, Beat
Soukup, Milan
An efficient enzymatic procedure for the enantio- and regioselective monohydrolysis of diethyl 2-isobutyl succinate 3 using subtilisin Carlsberg has been developed. The product (R)-2-isobutyl succinic acid 4-ethyl ester 4, a collagenase inhibitor building block, was obtained in high enantiomeric excess (> 99%) and yield (> 45%). Similarly, (R)-2-isobutyl succinic acid 4-nitrile 2 was produced in 98% ee from its ethyl ester 1.
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