Bioorganic and Medicinal Chemistry Letters p. 574 - 578 (2013)
Update date:2022-08-30
Topics:
Bailly, Fabrice
Toillon, Robert-Alain
Tomavo, Olympe
Jouy, Nathalie
Hondermarck, Hubert
Cotelle, Philippe
Caffeic acid derivatives are increasingly regarded as potential oncoprotective that could inhibit both the initiation and progression of cancer. Here we have synthesized seven 1-arylnaphthalene lignans and related compounds and tested their impact on breast cancer cell growth in tissue culture. The product of the oxidative dimerization of methyl caffeate, 1-phenylnaphthalene lignan, was found to induce a strong decrease in breast cancer cell number (IC50 ~1 μM) and was selected for further investigation. Flow cytometry analysis revealed a decrease in cell proliferation and an increase in apoptosis in both MCF-7 and MDA-MB-231 breast cancer cell lines that are representative of the two main categories of breast tumors. The 3,4-dihydroxyphenyl group probably induced the biological activity, as the control compounds lacking it had no effect on breast cancer cells. Together, our data indicate that the oxidative dimerization product of methyl caffeate can inhibit breast cancer cell growth at a concentration adequate for pharmacological use.
View MoreHEZE KINGVOLT CHEMICAL CO., LTD
Contact:86-573-82118911
Address:Juancheng Industry Park
Jiangsu Institute of Ecomones Co., Ltd
website:http://www.jsmone.com
Contact:+86-519-82821700
Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Shanghai Micro-mega Industry Co., Ltd.
Contact:0086-21-34628682;57153848
Address:Rm413,No.413,West Meilong Road, Minhang District,Shanghai P R China
Chengdu Baishixing Science and Technology Industry Co., Ltd.
website:http://www.cd-bsx.com
Contact:+86-28-88531548
Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
Zibo XiWeiLi Spice Limited Company
Contact:86-533-7220051
Address:Shandong province Zibo city Linzi Qilu Chemical Industrial Park South of ethylene, , China
Doi:10.1002/jlcr.2590110318
(1975)Doi:10.1039/c8cc05254a
(2018)Doi:10.1055/s-1999-2854
(1999)Doi:10.1002/chem.201704539
(2018)Doi:10.1080/10426500902754278
(2010)Doi:10.1039/c5ra24006a
(2016)