Journal of Chemical & Engineering Data
Article
indicating that polymorph A is the metastable form and
polymorph B is the stable form. Moreover, Tween 80 can
enhance the solubility of both polymorphs in the tested
solvents to almost the same extent and has a higher
solubilization capacity in acetone and a lower solubilization
capacity in IPA. The solubility of both polymorphs of erlotinib
hydrochloride increases linearly with the concentration of
Tween 80 in mixed solvents at a certain temperature.
(13) Xu, H.; Zhang, B.; Yang, Z. P.; Yao, G. B.; Zhao, H. K. Solubility
of dichloronitrobenzene in eight organic solvents from T= (278.15 to
3
03.15) K: measurement and thermodynamic modeling. J. Chem. Eng.
Data 2014, 59, 1281−1287.
14) El-Badry, M.; Haq, N.; Fetih, G.; Shakeel, F. Measurement and
correlation of tadalafil solubility in five pure solvents at (298.15 to
33.15) K. J. Chem. Eng. Data 2014, 59, 839−843.
15) Qian, C.; Wang, Y. Y.; Chen, X. Z. Solubility of 1-fluoro-4-
methylsulfonyl)benzene in five pure organic solvents at temperatures
from (288.40 to 331.50) K. J. Chem. Eng. Data 2014, 59, 1254−1256.
16) Wang, X. M.; Qin, Y. N.; Zhang, T. W.; Tang, W. W.; Ma, B. A.;
(
3
(
(
(
AUTHOR INFORMATION
■
Gong, J. B. Measurement and correlation of solubility of azithromycin
monohydrate in five pure solvents. J. Chem. Eng. Data 2014, 59, 784−
791.
(17) Jiang, P. P.; Wang, Z. Z. Solubility of p-aminobenzenesulfona-
Funding
mide in different solvents from (283.15 to 323.15) K. J. Chem. Eng.
The grants from the National Natural Science Foundation of
China (Nos. 21176102 & 21176215), the Natural Science &
Environmental Protection Foundations of Jiangsu Province
Data 2009, 54, 1945−1946.
(18) Hou, G. Y.; Yin, Q. X.; Zhang, M. J.; Su, W. Y.; Mao, H. L.;
Wang, J. K. Solubility of indinavir sulfate in different solvents from
(278.35 to 314.15) K. J. Chem. Eng. Data 2009, 54, 2106−2108.
(19) Dang, L. P.; Du, W. W.; Black, S.; Wei, H. Y. Solubility of
fumaric acid in propan-2-ol, ethanol, acetone, propan-1-ol, and water.
J. Chem. Eng. Data 2009, 54, 3112−3113.
(
No. BK20131100 & 2012004), City Level Subjects of
Shanghai University of Engineering and Technology (No.
4XKCZ04), and the Sino-German Center for Research
1
Promotion (No. GZ935) are sincerely acknowledged.
(20) Liu, J. Q.; Cao, X. X.; Ji, B. M.; Zhao, B. T. Measurement and
Notes
correlation of solubilities of indole-2-carboxylic acid in ten different
pure solvents from (278.15 to 360.15) K. J. Chem. Eng. Data 2013, 58,
The authors declare no competing financial interest.
3
(
309−3313.
21) Zhang, H. L.; Kong, C. Q.; Yang, S. J.; Bi, H. Y.; Li, J.
REFERENCES
■
Microcalorimetric studies on the CMC and thermodynamic functions
of a nonionic surfactant (Tween80) in DMF/long-chain alcohol
systems from T = 298.15 to T = 313.15 K. J. Solution Chem. 2011, 40,
(
1) Dowell, J.; Minna, J. D.; Kirkpatrick, P. Erlotinib hydrochloride.
Nat. Rev. Drug Discovery 2005, 4, 13−14.
2) Herbst, R. S.; Prager, D.; Hermann, R.; Fehrenbacher, L.;
(
6
(
32−642.
Johnson, B. E.; Sandler, A.; Kris, M. G.; Tran, H. T.; Klein, P.; Li, X.;
Ramies, D.; Johnson, D. H.; Miller, V. A. Tribute: a phase III trial of
erlotinib hydrochloride (OSI-774) combined with carboplatin and
paclitaxel chemotherapy in advanced non−small-cell lung cancer. J.
Clin. Oncol. 2005, 23, 5892−5899.
3) Lu, J.; Rohani, R. Polymorphism and crystallization of active
pharmaceutical ingredients (APIs). Curr. Med. Chem. 2009, 16, 884−
05.
4) Lu, J.; Wang, J.; Rohani, S. Preparation and characterization of
22) Zeng, Q. H.; Peng, S.; Liu, M.; Song, Z. J.; Wang, X. K.; Zhang,
X.; Hong, S. Solubilization and adsorption behaviors of 2,4,6-
trichlorophenol in the presence of surfactants. Chem. Eng. J. 2013,
2
(
30, 202−209.
23) Manorama, P.; Kabir, D. Solubilization of polycyclic aromatic
(
hydrocarbons by gemini-conventional mixed surfactant systems. J. Mol.
Liq. 2013, 187, 106−113.
9
(
(24) Mbah, C. J.; Ozuo, C. O. Effect of surfactants on the solubility
and intrinsic dissolution rate of sparfloxacin. Pharmazie 2011, 66,
92−194.
amorphous, I and II forms of clopidogrel hydrogen sulfate. Cryst. Res.
Technol. 2012, 47, 505−510.
5) Choi, W. S.; Kim, K. J. Solubility of forms I and II of clopidogrel
1
(
hydrogen Sulfate in methanol and 2-propanol mixture. J. Chem. Eng.
Data 2011, 56, 43−47.
(
6) Yang, X.; Wang, X. J.; Ching, C. B. Solubility of form α and form
β of glycine in aqueous solutions. J. Chem. Eng. Data 2008, 53, 1133−
137.
7) Tien, Y. C.; Su, C. S.; Lien, L. H.; Chen, Y. P. Recrystallization of
1
(
erlotinib hydrochloride and fulvestrant using supercritical antisolvent
process. J. Supercrit. Fluids 2010, 55, 292−299.
(
8) Karunakara, C.; Apama, U.; Chandreqowda, V.; Reddy, C. G.
Separation and determination of process-related impurities of erlotinib
using reverse-phase HPLC with a photo-diode array detector. Anal. Sci.
2
(
012, 28, 305−308.
9) Zhang, G. Z.; Zha, L. L. Isolation of highly pure erlotinib
hydrochloride by recrystallization after nucleophilic substitution of an
impurity with piperazine. Res. Chem. Intermed. 2013, 39, 2303−2309.
(
10) Lu, J.; Lin, Q.; Li, Z.; Rohani, S. Solubility of L-phenylalanine
anhydrous and monohydrate forms: experimental measurements and
predictions. J. Chem. Eng. Data 2012, 57, 1492−1498.
(
11) Bhesanyia, K.; Nandha, K.; Baluja, S. Thermodynamics of
fluconazole solubility in various solvents at different temperatures. J.
Chem. Eng. Data 2014, 59, 649−652.
(
12) Guo, Y. H.; Yin, Q. X.; Hao, H. G.; Zhang, M. J.; Bao, Y.; Hou,
B. H.; Chen, W.; Zhang, H.; Cong, W. Measurement and correlation
of solubility and dissolution thermodynamic properties of furan-2-
carboxylic acid in pure and binary solvents. J. Chem. Eng. Data 2014,
59, 1326−1333.
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dx.doi.org/10.1021/je500482k | J. Chem. Eng. Data 2014, 59, 2665−2669