Journal of Medicinal Chemistry p. 943 - 946 (1982)
Update date:2022-08-11
Topics:
Barbier, Pierre
Benezra, Claude
The enantiomers of γ-methyl-α-methylene-γ-butyrolactone have been prepared stereospecifically from (R)- and (S)-glutamic acid.Three groups of guinea pigs have been sensitized (Feund complete adjuvant technique) to the (+)-isomer, the (-)-isomer, and the (+/-)-mixture.The animals have been tested with each of the enantiomers and with a mixture of the compounds.Only the (-) enantiomer showed some specificity: guinea pigs sensitized to this enantiomer react weakly to the other compound; in turn, animals sensitized to the (+) enantiomer react similarly to both antipodes.Interestingly, reaction to the (+/-) mixture in each group of guinea pigs was the sum of skin responses to the individual enantiomer.These results should be contrasted with sensitization to (+)- and (-)-frullanolides, sesquiterpene lactones for which strong stereospecificity was observed.
View MoreLiaoyang Xinyou Chemical Products Co.,Ltd.
Contact:+86-419-5165433 13604191870
Address:Huishang Road6-1, Hongwei District, Liaoyang, Liaoning, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Hunan Dinuo Pharmaceutical Co.,Ltd.
Contact:86-731-88280100*8561
Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Tangshan Wisdom Trading Co.,Ltd
Contact:86 315 2222979
Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
Jinan Trio PharmaTech Co., Ltd
Contact:86-531-88811783;+(0)13153010282
Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
Doi:10.1016/j.crci.2012.03.003
(2012)Doi:10.1080/00397919808007045
(1998)Doi:10.1016/0039-6028(89)90001-0
(1989)Doi:10.1007/s00044-015-1321-0
(2015)Doi:10.1016/j.cclet.2009.10.013
(2010)Doi:10.1002/anie.200605201
(2007)