Organic Letters
Letter
oxidation step. Alternatively, a monoreduced diketo inter-
mediate in the reduction of 32 is dehydrated to 34.
ACKNOWLEDGMENTS
■
We are grateful to SERB-DST (YSS/2014/000792) for
funding this research and fellowships to N.S., Prof. Raja Roy,
Director of CBMR, Lucknow, for providing research facilities,
Prof. Werner Hummel, University of Bielefeld, for providing
the plasmid of glucose dehydrogenase, Shailesh Kumar Singh
and Amit Mondal, Centre of Biomedical Research, for skillful
T HNR of M. grisea catalyzes the reduction of a number of
4
2
-hydroxynaphthoquinones such as 10, 2, 7, 29, and 32. We
propose the involvement of this and related enzymes in the
biosynthesis of further dihydroarenediols such as nodulones.
Nodulones are a class of naphthalenones with a cis- or trans-
ketodiol substructure (35−41). They have been isolated from
endophytic fungi and display a diverse array of biological
assistance, and Dr. Wolfgang Huttel, University of Freiburg, for
̈
helpful suggestions.
15−20
activities (Figure 2).
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1
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4
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ASSOCIATED CONTENT
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4
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AUTHOR INFORMATION
■
(
(
Artiles, P.; U’Ren, J. M.; Arnold, A. E.; Gunatilaka, A. A. L. J. Nat.
Prod. 2018, 81, 616.
ORCID
Notes
The authors declare no competing financial interest.
Takaoka, S.; Kawase, M.; Sato, M.; Tsunoda, T. Furanaphin.
D
Org. Lett. XXXX, XXX, XXX−XXX