Bioorganic Chemistry p. 111 - 116 (2016)
Update date:2022-08-10
Topics:
Rashid, Umer
Rahim, Fazal
Taha, Muhammad
Arshad, Muhammad
Ullah, Hayat
Mahmood, Tariq
Ali, Muhammad
Sixteen 4-hydroxycoumarin derivatives were synthesized, characterized through EI-MS and 1H NMR and screened for urease inhibitory potential. Three compounds exhibited better urease inhibition than the standard inhibitor thiourea (IC50 = 21 ± 0.11 μM) while other four compounds exhibited good to moderate inhibition with IC50 values between 29.45 ± 1.1 μM and 69.53 ± 0.9 μM. Structure activity relationship was established on the basis of molecular docking studies, which helped to predict the binding interactions of the most active compounds.
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