Bioorganic and Medicinal Chemistry Letters p. 5229 - 5233 (2016)
Update date:2022-08-10
Topics:
Giannouli, Vassiliki
Lougiakis, Nikolaos
Kostakis, Ioannis K.
Pouli, Nicole
Marakos, Panagiotis
Skaltsounis, Alexios-Leandros
Nam, Sangkil
Jove, Richard
Horne, David
Tenta, Roxane
Pratsinis, Harris
Kletsas, Dimitris
A number of new 3,7-disubstituted pyrazolo[3,4-c]pyridines have been designed and synthesized from suitable 2-aminopyridines. The antiproliferative activity of the derivatives was determined against the pancreatic MIA PaCa-2 and ovarian SCOV3 cancer cell-lines. IC50values of the most promising analogue 46 lie in the submicromolar or low micromolar range. Furthermore, compound 46 shows similar inhibitory activities against DU145, A2058 and PC-3 cancer cells, blocks the cell cycle at the G0/G1phase and induce apoptosis, as determined by the appearance of apoptotic nuclei.
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Doi:10.3390/molecules26144309
(2021)Doi:10.1016/0040-4039(95)00816-U
(1995)Doi:10.1039/c1cc12024g
(2011)Doi:10.1002/jlcr.1535
(2008)Doi:10.1016/S0040-4039(00)94864-0
(1985)Doi:10.3184/174751913X13636339694414
(2013)