Bioorganic and Medicinal Chemistry Letters p. 3095 - 3100 (1997)
Update date:2022-08-17
Topics:
Schou, Charlotte
Ottosen, Erik R.
Petersen, Hans Jorgen
Bjoerkling, Fredrik
Latini, Scilla
Hjarnaa, Pernille V.
Bramm, Erik
Binderup, Lise
4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6-chlorophenoxyhexyl)-N'-cyano-N''-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of tumours in a model of NYH inoculated nude mice.
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