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phenylalanines. In contrast, about 30% of linear M-PEGs 24 There are no conflicts to declare.
was biodegraded when treated with SD rat plasma for 72
DOI: 10.1039/C8CC09151J
Notes and references
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Figure 3 Turbidity curves of M-PEGs 18 and 24 (a) and their
sequential turbidity photos (b, tube 1 to 4 contains 24 (3.0
mM), 24 (1.2 mM), 18 (3.0 mM) and 18 (1.2 mM).), and plasma
stabilities of M-PEGs 15, 17, 18 and 24 (c).
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hours. Allocation of M-PEGs fragments at side chains could
dramatically improve the stability of peptidic M-PEGs.
Worm, F. R. Wurm, H. Frey, Chem. Rev. 2016, 116, 21703; (e)
J. Cui, M. Björnmalm, Y. Ju, F. Caruso, Langmuir, 2018, 34,
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0817.
In summary, we have developed a cyclic sulfate-based
strategy for the convenient synthesis of branched M-PEGs AAs
and applied them to the synthesis of highly branched and
multifunctionalized peptidic M-PEGs “brushes” which showed
high biocompatibility, fine-tunable lipophilicity, improved
thermo-stability and plasma stability. Through structure-
property relationship studies, it was found that the properties
of the M-PEGs “brushes” are originated from their peculiar
mode of molecular geometry. SPPS facilitates the rational
programming of the structure, physicochemical and biological
properties. It is noteworthy that these accurate and
quantitative studies are largely based on the monodispersity of
these materials. Currently, polydisperse PEGs and their block
copolymers are overwhelmingly used in materials and life
sciences even though their heterogeneity issues are obvious,
which compromises research data and hampers quantitative
research. It would be highly beneficial to replace polydisperse
PEGs with monodisperse PEGs when accurate and quantitative
data is crucial for a study. Besides the discovery of novel M-
PEGs “brushes” and their peculiar properties, this study
opened an avenue to the next generation of biomaterials,
which have monodisperse component, programmable and
fine-tunable chemical structure and physicochemical
properties, and beyond.
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We are thankful for financial support from the National Key
R&D Program of China (2016YFC1304704), the National
Natural Science Foundation of China (21572168) and Hubei
Natural Science Foundation (2017CFA024).
Conflicts of interest
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| Chem. Commun., 2012, 00, 1-3
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