Journal of Organic Chemistry p. 11186 - 11194 (2019)
Update date:2022-08-11
Topics:
Mao, Jia
Zhang, Hao
Ding, Xiang-Feng
Luo, Xiaoyan
Deng, Wei-Ping
A catalytic asymmetric [3 + 2] cycloaddition of 2-indolylmethanols with α,β-unsaturated aldehydes was developed for the first time. This transformation was achieved by a synergistic catalytic system consisting of a palladium complex, a Br?nsted acid, and a chiral secondary amine to synthesize biologically active cyclopenta[b]indole derivatives with excellent diastereo- A nd enantioselectivities (up to >20:1 dr, up to 99% ee).
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