2
-Amino-5-methanesulfonylaminobenzenesulfonamide
1915
ꢀ
1
(
2
54.0 g, 80%) as a grey solid: mp ¼ 203–204 C; H NMR (DMSO-d ) d:
6
.86 (3H, s), 5.77 (2H, bs), 6.76 (1H, d, J ¼ 8.6), 7.11 (1H, dd, J ¼ 2.4,
1
1
3
J ¼ 8.6), 7.25 (2H, s), 7.43 (1H, d, J ¼ 2.1), 9.16 (1H, s); C NMR
2
(
for C H N O S : C, 31.69; H, 4.18; N, 15.84. Found: C, 32.02; H, 4.23;
DMSO-d ) d: 39.3, 118.1, 123.5, 124.8, 126.1, 129.6, 144.0. Anal. calcd.
6
7
11
3
4 2
N, 15.83.
ACKNOWLEDGMENT
The authors thank Drs. David Kucera, Jerry (Lijian) Chen, and David
Ellis for many helpful discussions during the course of this work.
REFERENCES
1
. (a) Krueger, A. C.; Madigan, D. L.; Green, B. E.; Hutchinson, D. K.; Jiang,
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2
. For other syntheses of N-(4-nitrophenyl)methanesulfonamide, see (a) Lee, J.;
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[
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3
4
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. For other recent applications of this literature procedure to the synthesis
of related 2-aminobenzenesulfonamides, see Rockway, T. W.; Zhang, R.;