C O M M U N I C A T I O N S
Table 1. Olefinic Ester Cyclizations
carried out thus far in our hands has been 0.5 g), we believe that
these studies represent a significant breakthrough. The reduced
titanium reagent described here is relatively inexpensive, it is
generated in situ, and it is tolerant of a wide variety of functionality.1c
We intend to continue to study the scope of its reactivity.
Acknowledgment. We are grateful to the National Institutes
of Health, General Medical Sciences (GM56677) for support of
this work. We would like to thank the support staff at the University
of Utah and especially Dr. Charles Mayne (NMR) and Dr. Jim
Muller (mass spectrometry) for help in obtaining data. We would
also like to thank Professor Gary Keck and Mr. Lars Heumann for
graciously providing the homoallyl alcohol precursor to 22, 24, and
26.
Supporting Information Available: General experimental proce-
dure for the cyclization reaction and spectroscopic data for all new
cyclic compounds. This material is available free of charge via the
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we have not explored the effect of stoichiometry or additives nor
have we focused on the scale-up of the reaction (the largest scale
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