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RSC Advances
Page 10 of 11
DOI: 10.1039/C5RA10486F
Journal Name
ARTICLE
12 J. F. Lutz, O. Akdemir and A. Hoth, J. Am. Chem. Soc., 2006,
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13 J. F. Lutz and A. Hoth, Macromolecules, 2006, 39, 893-896.
14 Y. H. Lim, G. S. Heo, Y. H. Rezenom, S. Pollack, J. E. Raymond,
polymer−polymer conjugaꢀon via click chemistry is still on-going in
our lab and will be presented in our future work.
M. Elsabahy and K. L. Wooley, Macromolecules, 2014, 47
4634-4644.
15 J. R. Kramer and T. J. Deming, J. Am. Chem. Soc., 2014, 136
5547-5550.
16 X. Fu, Y. Shen, W. Fu and Z. Li, Macromolecules, 2013, 46
3753-3760.
,
,
,
Conclusions
A series of MTC monomers bearing OEGs with thioether or/and
sulphone linkages were synthesized firstly through a sequence of
highly-efficient thio-bromo reaction, cyclization and oxidation. The
polymerization kinetics of the monomers and GPC results of the 17 D. L. Liu, X. Chang and C. M. Dong, Chem. Commun., 2013,
49, 1229-1231.
18 E. A. Rainbolt, K. E. Washington, M. C. Biewer and M. C.
Stefan, J. Mater. Chem. B, 2013, 1, 6532-6537.
19 J. Hao, J. Servello, P. Sista, M. C. Biewer and M. C. Stefan, J.
Mater. Chem., 2011, 21, 10623-10628.
products have indicated a good control of polymerization by using
DBU/TU as the catalyst. Then, the correlations between the LSCT
and molecular weight of polymer, concentration of polymer as well
as ionic strength were studied in detail. Results showed that
oxidation of thioether to sulphone increased the LSCT of 20 Y. Cheng, J. Hao, L. A. Lee, M. C. Biewer, Q. Wang and M. C.
Stefan, Biomacromolecules, 2012, 13, 2163-2173.
21 J. Feng, R.-X. Zhuo and X.-Z. Zhang, Prog. Polym. Sci., 2012,
37, 211-236.
22 S. Tempelaar, L. Mespouille, O. Coulembier, P. Dubois and A.
P. Dove, Chem. Soc. Rev, 2013, 42, 1312-1336.
polycarbonate within body temperature range and made it slightly
sensitive to the change of solution condition. Cytotoxicity assays
indicated that these polycarbonates have little toxicity. By
copolymerizing MTCs with different length of OEGs and linkages
(thioether or sulphone), the LCST of polycarbonates can be 23 J. W. Xu, E. Feng and J. Song, J. Appl. Polym. Sci. 2014, 131
39822.
,
accurately tuned on demand by changing the initial compositions of
monomers, and showed linear function of the monomer
24 H. Ajiro, Y. Takahashi and M. Akashi, Macromolecules, 2012,
45, 2668-2674.
a
compositions. In addition, the block polycarbonates with two
tunable LCSTs were constructed. LCST1 and LCST2 were achieved by
polymerization of monomers with hydrophobic thioether and
hydrophilic sulphone linkages, respectively. With these unique
properties, our novel biodegradable and thermoresponsive
polycarbonates are promising candidates for applications in
biomedical field.
25 S. Onbulak, S. Tempelaar, R. J. Pounder, O. Gok, R. Sanyal, A.
P. Dove and A. Sanyal, Macromolecules, 2012, 45, 1715-
1722.
26 Z. X. Voo, M. Khan, K. Narayanan, D. Seah, J. L. Hedrick and Y.
Y. Yang, Macromolecules, 2015, 48, 1055-1064.
27 A. C. Engler, X. Ke, S. Gao, J. M. W. Chan, D. J. Coady, R. J.
Ono, R. Lubbers, A. Nelson, Y. Y. Yang and J. L. Hedrick,
Macromolecules, 2015, 48, 1673-1678.
28 S. Venkataraman, J. L. Hedrick and Y. Y. Yang, Polym. Chem.,
2014, 5, 2035-2040.
29 S. Q. Liu, C. Yang, Y. Huang, X. Ding, Y. Li, W. M. Fan, J. L.
Hedrick and Y. Y. Yang, Adv. Mater., 2012, 24, 6484-6489.
30 R. J. Ono, S. Q. Liu, S. Venkataraman, W. Chin, Y. Y. Yang and
J. L. Hedrick, Macromolecules, 2014, 47, 7725-7731.
31 28.J. Liu, W. Liu, I. Weitzhandler, J. Bhattacharyya, X. Li, J.
Wang, Y. Qi, S. Bhattacharjee and A. Chilkoti, Angew. Chem.
Int. Edit, 2015, 54, 1002-1006.
Acknowledgements
This work is financially supported by National Natural Science
Foundation of China (21274085) and Shanghai Leading Academic
Discipline Project (no. B202).
32 A. B. EbrahimAttia, P. Oh, C. Yang, J. P. Tan, N. Rao, J. L.
Hedrick, Y. Y. Yang and R. Ge, Small, 2014, 10, 4281-4286.
33 B. B. Uysal, U. S. Gunay, G. Hizal and U. Tunca, J. Polym. Sci.
Pol. Chem., 2014, 52, 1581-1587.
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