Organic Process Research and Development p. 901 - 910 (2016)
Update date:2022-08-10
Topics:
Abrams, M. Leigh
Buser, Jonas Y.
Calvin, Joel R.
Johnson, Martin D.
Jones, Bradley R.
Lambertus, Gordon
Landis, Clark R.
Martinelli, Joseph R.
May, Scott A.
McFarland, Adam D.
Stout, James R.
Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxynaphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow reactor (PFR). The regio- and enantioselectivity of the AHF reaction provide a chemical probe of gas-liquid mixing in a flow reactor for comparison with well-stirred batch reactors. Results obtained with the flow reactor compare favorably to those obtained in batch. Thus, AHF provides an efficient, in-flow enantioselective synthesis of (S)-Naproxen.
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