Synthetic Communications p. 4049 - 4053 (2004)
Update date:2022-08-17
Topics:
Lu, Liang
Chen, Fener
A convenient and efficient synthetic route to Coenzyme Q1 (6) starting from 3,4,5-trimethoxytoluene (1) is described. The key features of this synthesis include the Diels-Alder reaction of 2,3-dimethoxy-1,4-benzoquinone (3) with cyclopentadiene and the introduction of a C5 side chain to 4,5-dimethoxy-2-methyltricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-dione (4) under mild conditions, (6) was obtained in overall 60% yield.
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