Journal of Heterocyclic Chemistry p. 1309 - 1314 (2000)
Update date:2022-08-11
Topics:
Katritzky
Denisenko
Denisenko
Arend
A simple one-pot procedure for the regioselective synthesis of pyrazoles from readily available starting materials is described. Vilsmeier type reagent 1 reacts with imines 10 (via the corresponding tautomeric secondary enamines) in tetrahydrofuran to give enaminoimine hydrochlorides 11. Nonsymmetrical imines generally react preferentially with 1 at the sterically less hindered α-position. The enaminoimine hydrochlorides 11 are transformed in situ to the corresponding pyrazoles 12 in moderate to high yields by the addition of hydrazine.
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Doi:10.1007/BF00478087
()Doi:10.1002/hlca.19800630609
(1980)Doi:10.1002/(sici)1099-1395(199704)10:4<221::aid-poc868>3.0.co;2-b
(1997)Doi:10.3762/bjoc.9.123
(2013)Doi:10.1016/j.molliq.2021.115798
(2021)Doi:10.1002/hc.20216
(2006)