Bioorganic and Medicinal Chemistry Letters p. 973 - 978 (1999)
Update date:2022-08-29
Topics:
Degen, Shane J.
Mueller, Kristen L.
Shen, Hong C.
Mulder, Jason A.
Golding, Geoffrey M.
Wei, Lin-li
Zificsak, Craig A.
Neeno-Eckwall, Amy
Hsung, Richard P.
A general approach to synthesis of dihydroxanthone derivatives is described here. In vitro evaluation of these dihydroxanthones demonstrated that some derivatives possess moderate anti-cholinesterase activities and better selectivities than tacrine for acetylcholinesterase over butyrylcholinesterase. Structural effects on anti-cholinesterase activities were also examined, and docking experiments were carried out to provide preliminary understandings of these experimental observations.
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