Journal of Pharmaceutical Sciences p. 998 - 1004 (1995)
Update date:2022-08-29
Topics:
Nudelman
De Waisbaum
In the acid hydrolysis of diazepam (1), several unusual products, apart from 2-(N-methylamino)-5-chlorobenzophenone (2) and glycine, were isolated. On the assumption that some of those products could arise from further degradation of 2, the reaction of this compound with 0.5-2 M HCl was studied, in 1:1 MeOH-H2O, at 60 and 80 °C. Several unexpected products were isolated from the reaction of 2 with HCl, namely, 2-amino-5-chlorobenzophenone (3), 2- (N,N-dimethylamino)-5-chlorobenzophenone (4), 2-(N-methylamino)-3,5- dichlorobenzophenone (5), 2-amino-3,5-dichlorobenzophenone (6), 2,4-dichloro- 10-methyl-9,10-acridinone (7), and 2,4-dichioro-9,10-acridinone (8). The methyl transfers, the chlorination, and the cyclization reactions that give rise to products 3-8 are unexpected under the present reaction conditions. The rate of reaction of 2, as well as the rate of formation of compounds 3- 6, was measured at several HCl concentrations.
View MoreContact:86-571-85586718
Address:join hands science park,NO.4028 nanhuan road,hanghzou ,zhejiang,china
Goldwills Pharmaceuticals Co., Ltd.
Contact:0916-2237889 13991621155
Address:North Suburb of Hanzhong city, Shaanxi Province
NanJing KaiHeng Chemical CO., LTD.
Contact:+86-25-85768391
Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Rizhao Lanxing Chemical Indusrial Co.,Ltd
Contact:86-633-2616708
Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
HANGZHOU PANYU CHEMICAL CO.,LIMITED
Contact:+86-571-86578491
Address:Rm 605, NO.1870 Binsheng Road,Binjiang Dist, Hangzhou, China
Doi:10.1002/aoc.5901
(2020)Doi:10.1016/j.cattod.2019.06.063
(2021)Doi:10.1021/acs.joc.8b01266
(2018)Doi:10.1007/s11164-020-04297-3
(2021)Doi:10.1021/ol2019899
(2011)Doi:10.1016/j.tetlet.2011.12.076
(2012)