Heterocyclic Communications p. 101 - 108 (2007)
Update date:2022-08-17
Topics:
Yu, Gang
Yamashita, Mitsuji
Aoshima, Kengo
Kobayashi, Masatsugu
Kato, Tatsunori
Kamikage, Nao
Takahashi, Masaki
Takayanagi, Hisao
Oshikawa, Tatsuo
Laurent, Sofie
Burtea, Carmen
Vander Elst
Muller, Robert N.
Takehara, Yasuo
Sakahara, Harumi
To improve the poor properties of currently clinically used MRI contrast agent of Gd-DTPA (Gadolinium-Diethylenetriamine-N,N,N',N",N"- pentaacetic acid) complex, sugar dendritic derivatives which contains Gd-DTPA as the core part and four or twelve sugars as the terminal part, dendrimer 8(Gd-DTPA-D1Glc(OAc)) or dendrimer 10(Gd-DTPA-D2Glc(OAc)), respectively, were prepared. From the result of relaxivity profile of these Gd complexes depending on temperature and magnitude of magnetic field, the smaller size MRI contrast agent of Gd-DTPA, 8(Gd-DTPA-D1Glc(OAc)), showed similar behavior to that of Gd-DTPA and the dendrimer constructs DDS of Gd-DTPA and was proven to have the improved properties for MR imaging of blood vessel (MRA) as well as for targeting specific organs.
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(2007)