Natural Product Research p. 776 - 781 (2014)
Update date:2022-08-16
Topics:
Ebada, Sherif S.
Fischer, Thomas
Hamacher, Alexandra
Du, Feng-Yu
Roth, Yoen Ok
Kassack, Matthias U.
Wang, Bin-Gui
Roth, Eckhard H.
Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketide derivatives (4-6). The chemical structure and relative and absolute configurations of psychrophilin E (1) were unambiguously established based on HRMS, 1D, 2D NMR and chiral-phase HPLC analysis of its hydrolysate. All the isolated compounds were assessed for their anti-proliferative activity against four different human cancer cell lines and some of them revealed selective activities. 2014
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