ChemComm
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DOI: 10.1039/C6CC08213K
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Scheme 4. Suggested mechanism.
a freeꢀradicalꢀtriggered CDC reaction of
heterocycles with simple nitriles is developed. Through this novel
strategy, a wide range of Cꢀ2 cyanoalkylated heterocycles such as
furan, thiophene, indole, and pyrrole can be synthesized siteꢀ
specifically. This example further shows that highly selective
functionalization of inert CꢀH bond can be achieved and wellꢀ
controlled by radical promotion in some cases.
10 This project is supported by the National Natural Science
Foundation of China (Nos. 21272096, 21472080, 21672089), the
Program for Changjiang Scholars and Innovative Research Team
in University (PCSIRT: IRT15R28), and the Fundamental
Research Funds for the Central Universities (lzujbkyꢀ2016ꢀ50,
15 lzujbkyꢀ2016ꢀct02).
In summary,
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Notes and references
† School of Petrochemical Engineering, Jiangsu Key Laboratory of
Advanced Catalytic Materials and Technology, Changzhou University,
Changzhou 213164, P. R. China; Eꢀmail: liuzhq@lzu.edu.cn
20 ‡ State Key Laboratory of Applied Organic Chemistry, Lanzhou
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§ College of Chemistry & Environmental Science, Hebei University,
Baoding, Hebei, 071002, P. R. China
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