Nucleosides, nucleotides and nucleic acids p. 1649 - 1652 (2007)
Update date:2022-08-10
Topics:
Oliviero, Giorgia
Amato, Jussara
D'Errico, Stefano
Borbone, Nicola
Piccialli, Gennaro
Mayol, Luciano
The synthesis and the use of new N-1-dinitrophenyl-inosine based solid support is reported. The support, which binds the nucleoside by a 5′-O-monomethoxytrityl function, reacting with N-nucleophiles allowed the synthesis of a small library of N-1 alkylated inosine and AICAR derivatives. Moreover, the obtained supports, after the cleavage of the 2′ -3′ ribose bond, furnished a set of new N-1 alkylated-2′ -3′ -secoinosine derivatives in high yields. Copyright Taylor & Francis Group, LLC.
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