Communication
ChemComm
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confirmed the negligible-toxicity and remarkable biocompat-
ibility of PPAB NPs in vivo as well as highlighted the great
potential of PPAB NPs for PTT.
In summary, we have successfully synthesized an efficient
photosensitizer, Pyrrolopyrrole aza-BODIPY (PPAB, for PAI- and
NIR-FI-guided PTT). As-prepared PPAB NPs showed remarkable
photostability in an aqueous solution and a high PTC efficiency
of 47%. With the use of PPAB NPs as a photothermal agent,
in vitro experiments demonstrated excellent tumor ablation
ability, even at a low concentration. For in vivo PTT, PPAB
NPs did not cause any significant toxicity in mice. Results
demonstrated that 100% tumor elimination was realized under
a 730 nm laser (0.75 W cmÀ2). It is believed that PPAB NPs will
play a prominent role in clinical dual-modality imaging-guided
PTT in the near future.
The study was supported by the NNSF of China (61525402,
61775095, and 61604071), Jiangsu Provincial key research and
development plan (BE2017741), and the Natural Science Foun-
dation of Jiangsu Province (BK20161012).
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Conflicts of interest
The authors of this manuscript have no conflicts of interest.
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