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13. To confirm selectivity of this reaction the formed phosphate ester was acylated with an excess of S-(+)-MTPA
chloride in pyridine10,16 resulting in a large downfield shift of the methine H-3 proton (DlCDCl =1.33 ppm) and
3
a small upfield shift of the methylene H-1 protons (DlCDCl =0.30 (Ha-1) and 0.10 (Hb-1) ppm, respectively). In
3
1
1
addition, the recorded H and 13C NMR spectra of the 3-O-MTPA derivative of 6 showed only one set of H
and 13C resonance signals.
14. Compounds 3 and 4a were identical with or match the reported data with respect to TLC, NMR and MS.9f,g,k
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