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ChemComm
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poor dispersion of free alamethicin may lead to higher MIC
and MBC (Table 1). In contrast, alamethicin entrapped by
polymeric carrier could be dispersed well without aggregation
(
3
1
1
2 L. G. Miller, F. Perdreau-Remington, G. Rieg, S. Mehdi, J. Perlroth,
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Fig. 2), and be quickly released from the assembly complex at
7 1C (Fig. S5, ESI†) due to the UCST of the polymeric carrier
Fig. 1C). The released alamethicin was evenly distributed with
high concentration in the media, thereby killing bacteria
effectively (Table 1). Therefore, the thermo-sensitive polymeric
1
(
674–678.
1
4 D. Styers, D. J. Sheehan, P. Hogan and D. F. Sahm, Ann. Clin.
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against Staphylococcus aureus.
In summary, we show a strategy for enhanced antibacterial
activity of alamethicin against Staphylococcus aureus by a
thermo-sensitive polymeric carrier. A similar concept should
be applicable to the delivery of other AMPs against microbial
500–510.
18 B. Leitgeb, A. Szekeres, L. Manczinger, C. Vagvolgyi and L. Kredics,
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This work was supported by the Natural Science Foundation
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2 J. Chen, F. Wang, Q. Liu and J. Du, Chem. Commun., 2014, 50,
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by the Priority Academic Program Development of Jiangsu Higher
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Province, and Jiangsu Key Laboratory of Radiation Medicine 23 A. Singh, M. Talekar, T. H. Tran, A. Samanta, R. Sundaram and
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