Human Somatostatin Receptor Specificity
J ournal of Medicinal Chemistry, 2002, Vol. 45, No. 8 1671
emerging peaks (i.e., fragments) that were derived from the
peptide as compared to the control blank chromatogram. All
experiments were repeated three times; the data were ex-
pressed as mean ( SEM. The comparisons between groups
were analyzed by one way analysis of variance for repeated
measures at the 95% confidence level.
(11) Bitan, G.; Zeltser, I.; Byk, G.; Halle, D.; Mashriki, Y.; Gluhov,
E.; Sukhotinski, I.; Hanani, M.; Selinger, Z.; Gilon, C. Backbone
Cyclization of the C-terminal Part of Substance P: the Important
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12) Bitan, G.; Sukhotinsky, I.; Mashriki, Y.; Hanani, M.; Selinger,
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(
(
(
13) Reichlin, S.; Somatostatin: Historical aspects. Scand. J . Gas-
Ack n ow led gm en t. This study was financed by
Peptor Ltd., Rehovot Israel. S.G. thanks Dr. J oseph
Salitra, Dr. Tami Yechezkel, Dr. Asher Algawi, Dr.
Eliezer Falb, Dr. Dvira Shohat, Dr. Erez Gur, Mrs.
Manuela Lazarov, and Mrs. Elana Hariton for their
helpful discussions. Special thanks to Dr. Nurit Livnah
and Dr. Assaf Friedler for their critical review of this
work.
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Su p p or tin g In for m a tion Ava ila ble: The MS and amino
acid analysis of analogues 2-8 (Figure 1). This material is
available free of charge via the Internet at http://pubs.acs.org.
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