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ChemComm
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COMMUNICATION
Journal Name
process undergoes between intermediate D and oxidative PC+ to
afford the final product 3aa after deprotonation.
,
30650.
DOI: 10.1039/D0CC01333A
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Conclusions
In summary, a deaminative [4+2] annulation method has been
developed using photoredox catalysis under mild reaction
conditions, in which a broad range of isoquinolone derivatives
have been prepared without using directing groups in
moderate to good yields in the absence of metal catalyst. This
manifold well accepts various functional groups and shows
good efficacy. In addition both terminal and internal alkynes
are viable substrates in this protocol. We envision that this
strategy will inspire further applications in the synthesis of
natural products. However, this method suffers from atom-
economy limitation by losing triphenylpyridine from starting
material when compared with the metal-catalyzed strategy.
Therefore further investigations towards atom-economy
annulation and novel application of radical annulation reaction
in complicated molecules are ongoing in our laboratory.
We are grateful for the financial support from the National
Natural Science Foundation of China (Nos. 21901141 and
21672047 ) and the start-up funds of Quzhou University (No.
BSYJ201714).
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Conflicts of interest
There are no conflicts to declare.
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