Tetrahedron Letters p. 2883 - 2886 (1998)
Update date:2022-08-11
Topics:
Holton, Robert A.
Zhang, Zhuming
Clarke, Paul A.
Nadizadeh, Hossain
Procter, D. John
New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward.
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