Tetrahedron Letters p. 3895 - 3898 (2000)
Update date:2022-08-25
Topics:
Chou, Shan-Yen
Tseng, Chin-Lu
Chen, Shyh-Fong
A study of the stereoselective halogenation of 6,6-dimethyl-1-hepten-4- yn-3-ol (1) using a series of halogenating agents is described. Of the many agents investigated, boron trichloride is the most successful reagent for stereoselective halogenation (E:Z=9:1(max)). The resulting (E)-1-halo-6,6- dimethyl-2-hepten-4-yne (2), a key intermediate for terbinafine, an antifungal agent, is obtained in good yield and stereoselectivity. Two structurally related enyne alcohols have been studied likewise and shown similar versatility. (C) 2000 Elsevier Science Ltd.
View MoreZibo Fuxi'er Chemical Co.,Ltd (Shanxian Fuxi'er Chemical Co.,Ltd)
Contact:+86-533-2091422
Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Nanjing Samwon International Limited
Contact:+86-25-84873444
Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Contact:+49-9398-993127
Address:Untertorstr. 27
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Shanghai PuYi Chem-Tech Co.,Ltd.
Contact:+86-21-57687505-227
Address:3 Floor, Building 11, No 201 MinYi Road, Songjiang District, Shanghai 201612, China
Doi:10.1134/S0036023612060113
(2012)Doi:10.1039/c6ra04332a
(2016)Doi:10.1055/s-2006-944206
(2006)Doi:10.1021/acs.joc.5b01592
(2015)Doi:10.1002/prac.19963380192
(1996)Doi:10.3184/174751915X14400926401559
(2015)