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Scheme 5. Possible reaction mechanism.
In summary, we have disclosed a new palladium-catalyzed
cascade reaction for the assembly of a variety of aryl-substituted
spirocyclic oxindoles from N-(2-halophenyl)-2-(naphthalen-1-
yl)acrylamides with aryl iodides, which enables regioselective C2-
H arylation and C8-H alkylation of naphthalene ring through an
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Notably, this approach showcases broad substrate scope and good
functional group tolerance. Further studies toward exploring this
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We thank the National Natural Science Foundation of China
(Nos. 21572051, 21602057, 21901071, and 21971061), Natural
Science Foundation of Hunan Province (Nos. 2020JJ5350 and
2020JJ5347), Scientific Research Fund of Hunan Provincial
Education Department (Nos. 18A002, 19B359, and 17C1137),
and Science and Technology Planning Project of Hunan Province
(No. 2018TP1017) for financial support.
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