Nucleosides and Nucleotides p. 2155 - 2173 (1999)
Update date:2022-08-11
Topics:
Chheda
Patrzyc
Tworek
Dutta
Two new modified uracil nucleosides, 5-carbamoylmethyuridine (ncm5U, I) and 5-carbamoylmethyl-2-thiouridine (ncm5s2U, II) were isolated from a 24 hr collection of a normal human urine. The structures were assigned on the basis of UV, NMR and mass spectral data and confirmed by comparison of the spectral data and HPLC mobilities with those of authentic samples. On the basis of experimental data it appears possible that 5-carbamoylmethyl- 2-thio-uridine (ncm5s2U, II) may be a degradation product produced from a labile precursor by the chemical treatments during the isolation procedure. However, the other nucleoside (ncm5U,I) certainly appears to be of metabolic origin and was also found in the urines of one chronic myelogenous leukemia and one lung carcinoma patient.
View MoreNanjing Chemzam Pharmtech Co., Ltd.
Contact:+86-25-86462165,+86-13915979898
Address:C5-1,6 Maiyue Road,Maigaoqiao,Nanjing,Jiangsu,China
Zhejiang Rongkai Chemical Technology Co.,Ltd.
Contact:+86-578-8185786
Address:Shangjiang Industrial Zone,Suichang
Contact:+86-512-56795332
Address:No227 Shuanglong Rd, Fenghuang, Zhangjiagang
Contact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Zhejiang Allied Chemical Co.,Ltd
Contact:18967038207
Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Doi:10.1007/s12039-019-1592-y
(2019)Doi:10.1039/c39870001738
(1987)Doi:10.1021/ja01187a031
(1948)Doi:10.2174/1570178611310010005
(2013)Doi:10.1016/j.jcat.2011.06.025
(2011)Doi:10.1002/anie.200905642
(2010)