Nucleosides, nucleotides and nucleic acids p. 1075 - 1079 (2005)
Update date:2022-08-10
Topics:
Proupin-Perez
Cosstick
Liz-Marzan
Salgueirino-Maceira
Brust
A new method has been investigated for the functionalization of gold nanoparticles with DNA. Silica-coated nanoparticles functionalized with a maleimide have been prepared. These particles are designed to react with modified DNA containing a diene functionality at one end of the molecule. The result would be the formation of a more stable attachment of the DNA to the particle through a Diels-Alder reaction. This covalent attachment would not be susceptible to ligand exchanges, which are known to occur in the conventional DNA functionalization of gold nanoparticles. Copyright Taylor & Francis, Inc.
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Doi:10.1016/S0040-4020(01)93341-1
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