10.1002/chem.201605068
Chemistry - A European Journal
COMMUNICATION
COMMUNICATION
The first Ru-catalyzed C–H arylation
of benzoic acids with readily available
aryl (pseudo)halides, allowing the
arylation of previously challenging
hindered benzoic acids and the use of
generally unreactive ortho-substituted
halorarenes. Furthermore, our new
protocol can efficiently be applied to
indole carboxylic acids, thus allowing
access to C7-, C6-, C5- and C4-
arylated indole compounds, a depar-
ture from the classical enhanced
reactivity of C2 and C3 in indole.
Marco Simonetti, Diego M. Cannas,
Adyasha Panigrahi, Szymon Kujawa,
Michal Kryjewski, Pan Xie and Igor
Larrosa*
Page No. – Page No.
Ruthenium-Catalyzed C–H Arylation
of Benzoic Acids and Indole Carbox-
ylic Acids with Aryl Halides
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29 With substrate 4g, a small amount of another arylation product was observed. Altoug h isolation was not possible, we speculate that (bis)arylation at C3 position could likely occur.
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