Journal of Inorganic and General Chemistry
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ARTICLE
Zeitschrift für anorganische und allgemeine Chemie
Synthesis of [Au(AEP)
adding 0.115 g (0.5 mmol) 2-(diphenylphosphanyl)ethylamine to gent blank. The experimental results are presented as micro-mole con-
Au(AEP)Cl] (1) (0.231 g, 0.5 mmol) (Au:AEP = 1:2) in dichloro- centration of 50% cell growth inhibition (IC50) of each compound.
2
]Cl (2): The bis complex (2) was prepared by 570 nm with Lab systems Multiskan EX ELISA reader against a rea-
[
methane (5 mL). A yellow solution appeared that was stirred for 3 h The MTT assay was performed in three independent experiments.
and filtered. The solution was concentrated by low evaporation of sol-
vent at room temperature. A yellow solid (2) was obtained that was
recrystallized from acetone/dichloromethane and dried overnight in Acknowledgements
–
1
2 2
vacuo. Yield 0.3 g (87%). C28H32AuClN P (690.68 g·mol ): calcd.
C 48.67; H 4.67; N 4.05%; found: C 47.89; H 5.52; N 4.04%. IR This project was funded by the National Plan for Science and Innova-
KBr): ν˜ = ν(N–H) 3421, 3332; ν(CH
) 2909asym, 2852sym, ν(C–H) tion (MARIFAH)–King Abdulaziz City for Science and Technology
275bend; ν(Ar–C=C) 1566; ν(N–C) 1496 cm . H NMR (CDCl
ppm): δ = 4.04, 3.13 (s, 2 H, NH); 3.02, 2.85 [m, C(1)H, H’]; 2.56,
(
1
2
–1 1
(KACST) through the Science and Technology Unit at King Fahd Uni-
versity of Petroleum and Minerals (KFUPM) of Saudi Arabia, award
Numbers 14-MED64–04 and 11-MED1670–04.
3
,
13
1
.26 [m, C(2)H, H’]; 7.33–7.74 (m, 20 H, C
ppm): δ = 36.63 C(1), 28.57 C(2), 129.17–133.08 C(C
CDCl , ppm): δ = 26.55.
5 5 3
H ). C NMR (CDCl ,
3
1
6 5
H ). P NMR
(
3
References
Synthesis of Gold(I)-Dithiocarbamate Complexes, [Au
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methane (10 mL) was added 1 equiv. of the respective dithiocarbamate
2 2 2 2 n
(R NCS ) ]
(
3 2
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3
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990, ν(C–H) 1375bend; ν(N–C) 1483; ν(C=S) 1100, 993 cm . H
13
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, ppm): δ = 3.55 (s, 6 H, CH
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3 3
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2
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[
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4
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970, ν(C–H) 1377bend; ν(–CH )2925asym, 2856sym; ν(–CH bend 1264;
, ppm): δ =
). C NMR (CDCl , ppm):
(1), 49.35 C(2), 12.20 C(3).
2 4 2 2
(C H10NCS ) (690.47 g·mol ): calcd. C 17.72; H 2.56; N
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2
2
)
–
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ν(N–C) 1480; ν(C=S) 1098, 1067 cm . H NMR (CDCl
3
13
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1.32 (t, 6 H, CH
3
), 3.92 (t, 4 H, CH
2
CH
3
3
[
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δ = 205.58 –NCS
2
–
1
5
2
2
: Au
.88%; found: C 37.58; H 3.05; N 3.02%. IR (KBr): ν˜ = ν(CH
923asym, 2850sym, ν(C–H) 1265bend; ν(Ar–C=C) 1602; ν(N–C) 1433;
2 2 2
(C14H14NCS ) (926.74 g·mol ): calcd. C 36.33; H 2.56; N
[
[
[
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2
)
–1 1
ν(C=S) 1100, 1072 cm . H NMR (CDCl
3
, ppm): δ = 4.85, 4.78 (d,
). C NMR (CDCl , ppm): δ =
(1), 54.27 C(2), 128.58–140.93 C(C
13
4
2
H, CH
2
), 7.17–7.77(m, 10 H, C
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H
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3
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H
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MTT Assay for in vitro Cytotoxicity of Complexes: The anticancer
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41]
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(
3
3
ϫ10 cells/well in 100 μL DMEM containing 10% Fetal Bovine Se-
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3
2
2
[
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[
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[
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