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ChemComm
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DOI: 10.1039/C7CC06553A
COMMUNICATION
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hours. These results show that DOX-loaded MH4ꢀβꢀCD-AcMH
nanoparticles are efficiently taken up by SW620 celles.
Conflicts of interest
There are no conflicts to declare.
Notes and references
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Fig. 4 Representative fluorescence images of SW620 cells
incubated with DOX-loaded MH4ꢀβꢀCD-AcMH nanoparticles (A)
for 0.5 h, (B) for 2h and (c) for 6h. For cell nuclei stained by
DAPI (blue), DOX fluorescence in cells (red), and overlays of
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the two images. Scale bar: 100 ꢁm.
In summary, tumor cells have relatively high concentrations
of ROS and are weakly acidic. We therefore designed and
prepared multi-sensitive oligosaccharide supramolecular
amphiphiles through host-guest recognition between
a
terminal Fc and βꢀCD. The supramolecular amphiphiles
demonstrated that an oligosaccharide can self-assemble in
water to provide well-distributed spherical nanoparticles with
an average particle size of 40 nm. The noncovalent βꢀCD/Fc
and acetal groups afforded supramolecular amphiphiles that
rapidly released the encapsulated drug in response to acid
conditions and NaClO. The properties of the protecting group
are critical for tuning the loading and release capacities of the
nanocarriers, making it possible to construct a series of
supramolecular amphiphiles based on polysaccharides. These
novel
materials,
composed
only
of
amphiphilic
ologosaccharides, have great potential for a wide range of uses.
Furthermore, their versatile chemical and physical properties,
such as biodegradability, biocompatibility, and nontoxicity,
make them attractive for further development. The present
work therefore provides a new platform for constructing drug
delivery and drug release carriers.
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and X. Zhang, Angewandte Chemie, 2011, 123, 5054; (f) C.
Wang, Q. Chen, H. Xu, Z. Wang and X. Zhang, Adv. Mater.,
2010, 22, 2553.
The authors would like to acknowledge the financial support
provided by the National Natural Science Foundation of China
(No. 21772080), the Natural Science Foundation of Gansu
Province (1506RJYA221), and the Fundamental Research Funds
for the Central Universities (lzujbky-2017-113, lzujbky-2016-
ct05).
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4 | J. Name., 2012, 00, 1-3
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