Journal of Fluorine Chemistry p. 385 - 402 (1981)
Update date:2022-08-10
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Hitzke,J.
The fluorinations of tetrachloropyrimidine, 2,4,6-trichloropyrimidine and trichloro-s-triazine were carried out in sealed tubes with KF in presence of inert gas and then compared.The fluorinated derivatives C4FxClyN2 with x + y = 4, O = x < 4, C4HFxClyN2 with x + y = 3, O = x = 3 and C3FxClyN3 with x + y = 3, O = x = 3 were obtained.The influence of contact time, temperature and concentration of the ion F- were investigated and compared; the molar yields were found to be always higher than 50percent in our experimental conditions.We compare with the fluorinations of 2,4 and 4,6-dichloropyrimidine.It is possible to obtain directlyin good proportions, such fluorinated derivatives as 5-chlorotrifluoropyrimidine, trifluoropyrimidine and others.At high temperature (4OO deg C for 16h), tetrachloropyrimidine, in presence of KF, gave products of pyrolysis and condensation such as the fluorinated derivatives of C6Cl6 and C5Cl5N: C6FCl5, C6F2Cl4... or C5FCl4N, C5F2Cl3N...
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