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Angewandte
Chemie
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In conclusion, we have successfully demonstrated a versa-
tile strategy for cooperative self-assembly of globular poly(l-
lysine) dendrimers with linear poly(l-leucine). After a two-
step hierarchical self-assembly, the nanoparticles possessed
a capsid-like biomimetic nanoarchitecture. The hierarchical
peptidesomes exhibited high gene-transfection efficiency as
nonviral gene vectors. The strategy of the hierarchical self-
assembly could also be applied for fabricating versatile
nanoarchitectures. A detailed study of the cooperative self-
assembly, such as precise regulation of the morphology and
medical applications, is being explored and will be reported in
our future publications.
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Received: August 27, 2011
Revised: November 15, 2011
Published online: February 8, 2012
Keywords: dendrimers · gene vectors · nanostructures ·
.
peptides · self-assembly
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