Journal of the American Chemical Society p. 3197 - 3204 (1985)
Update date:2022-08-11
Topics:
Lipshutz, Bruce H.
Kozlowski, Joseph A.
Breneman, Curt M.
Both 1H and 7Li NMR spectroscopy at high field have served to reveal that the addition of ethereal MeLi to MeCu/THF, in the absence of LiI, leads to unprecedented equilibria (Keq ca. 11) between Me2CuLi and MeLi plus Me3Cu2Li.From a series of spectra at -70 degC, a scheme is proposed to account for the signals observed in solutions of varying MeLi:MeCu ratios.These data lead to the conclusion that not only Gilman's reagent but also "Me3CuLi2" and "Me5Cu3Li2" are not discrete, but rather are composed of differing percentages of the same components.In the presence of LiI, or in Et2O solutions alone, however, this equilibrium does not exi sts for MeLi:MeCu ratios up to 1:1.Chemical tests on both ketones and esters, as well as a series of Gilman tests, fully corroborate the existence of various forms of Gilman's reagent.
View MoreKINHENG CHEMICAL(SHANGHAI)CO., LTD.
Contact:+8621-60490170
Address:Room401, No.28,Lane 189, Yangshupu Rd. Shanghai, China.
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Nantong Auxin Electronic Technology Co., LTD
Contact:86-513-88760026
Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Doi:10.1007/BF03376558
(1944)Doi:10.1039/jr9520001952
(1952)Doi:10.1016/S0040-4020(01)90410-7
(1994)Doi:10.1039/c5ra23271f
(2016)Doi:10.1021/acs.orglett.6b00438
(2016)Doi:10.1093/nar/gkv979
(2015)