Journal of Molecular Structure p. 84 - 91 (2017)
Update date:2022-08-30
Topics:
Araújo, éverton José Ferreira de
Silva, Oskar Almeida
Rezende-Júnior, Luís Mário
Sousa, Ian Jhemes Oliveira
Araújo, Danielle Yasmin Moura Lopes de
Carvalho, Rusbene Bruno Fonseca de
Pereira, Sean Telles
Gutierrez, Stanley Juan Chavez
Ferreira, Paulo Michel Pinheiro
Lima, Francisco das Chagas Alves
This study performed a physicochemical characterization of the inclusion complex generated between Riparin A and β-cyclodextrin (Rip A/β-CD) and compared the cytotoxic potential of the incorporated Rip A upon Artemia salina larvae. Samples were analyzed by phase solubility diagram, dissolution profile, differential scanning calorimetry, X-ray diffraction, infrared spectroscopy, proton nuclear magnetic resonance, scanning electron microscopy and artemicidal action. Riparin A/β-cyclodextrin complexes presented increased water solubility, AL type solubility diagram and Kst constant of 373?L/mol. Thermal analysis demonstrated reduction of the melt peak of complexed Rip A at 116.2?°C. Infrared spectroscopy confirmed generation of inclusion complexes, 1H NMR pointed out the interaction with H-3 of β-CD cavities, alterations in the crystalline natures of Rip A when incorporated within β-CD were observed and inclusion complexes presented higher cytotoxic on A.?salina nauplii, with CL50 value of 117.2 (84.9–161.8) μg/mL. So, Rip A was incorporated into β-CDs with high efficiency and water solubility of Rip A was improved. Such solubility was corroborated by cytotoxic evaluation and these outcomes support the improvement of biological properties for complexes between Riparin A/β-cyclodextrin.
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